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KMID : 1149220120200020093
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Korean Journal of Oriental Medical Prescription
2012 Volume.20 No. 2 p.93 ~ p.102
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Acute Toxicity Study on Gumiganghwal-tang and Fermented Gumiganghwal-tang Extracts
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Park Hwa-Yong
Hwang Yun-Hwan
Jang Doo-Rye
Ha Jeong-Ho
Jung Ki-Youn
Ma Jin-Yeul
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Abstract
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Objectives : Traditional medicine Gumiganghwal-tang (GT) has been used in Asia to treat inflammatory diseases including common cold, pain, fever, and algor. In this study we investigated the acute toxicity and safety of GT and fermented GT (FGT).
Methods : Acute toxicity and safety were evaluated in male and female ICR mice orally administered 0 (control) and 2,000 mg/kg of GT and FGT. After the administration of GT and FGT, we observed mortality, body weight, clinical symptoms. After necropsy, organ weights were measured and blood analysis was performed.
Results : There was no mortality and clinical symptoms according to the administration of GT and FGT. Comparing with control group, there were no significant alterations on the organ weight, complete blood cell count and biochemical parameters.
Conclusions : Median lethal dose of GT and FGT considered to be over 2,000 mg/kg in both male and female mice, and recognized as safe with no toxicity.
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KEYWORD
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Gumiganghwal-tang, Fermentation, Acute toxicity
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